A new study found that the gene Arih2 is the basis of the immune system's function and can play a decisive role in whether the immune response is turned on. Its discovery can bring new ideas for the treatment of chronic infections such as HIV, immune system diseases and chronic inflammatory diseases such as rheumatoid arthritis and sepsis. The research results were published in the journal Nature Immunology. Arih2 was found in sentinel dendritic cells of the immune system, which played a vital role in resisting foreign invaders. Arih2 is the most fundamental and most important determinant of whether an immune response should be turned on or off. If the wrong decision is made, the body will succumb to infection or develop autoimmune diseases. Our immune system works well and has established precise biological mechanisms for many infections to evade or fight infections. But in the course of evolution, some organisms have evolved to deplete our immune system, which is why we suffer from HIV, hepatitis B and tuberculosis. Dr. Ebert said the research team is analyzing the effect of shutting down Arih2 on the immune response to chronic infection in a short period of time. Arih2 has a unique structure, and we think it is a good drug target, but it will take years of research to develop a drug that targets this.
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