Parkinson's disease (PD) is a complex neurodegenerative disease that triggers many different symptoms in the elderly. These symptoms may be caused by the same pathway. At present, the diagnosis of Parkinson's disease mainly depends on clinical observation, laboratory standard tests or biosensors that cannot be established, to accurately and reliably identify this disease. And because some symptoms overlap with other diseases, especially in the early stage of the disease, it also causes challenges for the diagnosis of this disease. There is an urgent clinical need to develop biosensors for diagnosing the occurrence and development of this disease. Researchers have conducted research using quantum dots (QDs). Quantum dots are some tiny light-emitting crystals, because many of them are superior to the absorption and emission properties of organic dyes, including broad absorption spectrum, narrow emission spectrum, photobleaching resistance, etc. The potential for application in medicine is to use this crystal to observe image-guided surgery, light-activated therapy, and sensitive diagnostic tests. Studies have shown that the inhibition of NADH: ubiquinone oxidoreductase (complex I) in mitochondria may be the main cause of sporadic Parkinson's disease. This abnormality of complex I will cause the suppression of dopamine neurons, which will cause Parkinson's The main clinical symptoms of the disease. The association between loss of complex I activity and PD disorders will be used for early diagnosis and monitoring of PD. Therefore, the researchers built a complex I biosensor using ubiquinone-terminated disulphides with different alkyl intervals. Among them, the enhancement or quenching of QD bioluminescence can be used as a functional representation of the redox state of QnNS. Bioconjugated QnNS-QDs are stimulated by complex I in the presence of NADH to stimulate the mitochondrial respiratory chain electron transfer system, thus forming a kind of Complex I sensors in vivo and in cells. Researchers have confirmed through experiments that this QnNS-QDs system can monitor different complex I levels in SH-SY5Y cells, which can be used for early diagnosis of Parkinson's disease and monitoring of disease progression. Lash Boxes,Lash Box,Plastic Eyelash Case,Clear Lashes Boxes Zhengzhou Cuka Electronic Commerce Co., Ltd. , https://www.cukalashes.com