The research stems from Dr. Wang ’s desire to better understand the epigenetic regulation of stem cell differentiation. Epigenetic regulation refers to the change in the structure of a gene, but the DNA sequence of the gene has not changed. Dr. Wang and his research team found two The gene activation enzymes KDM4B and KDM6B promote the differentiation of stem cells into bone cells by removing the methyl tag on histones. This process is through the activation of genes that support the differentiation of stem cells into one cell line, while allowing the differentiation of stem cells into other cell lines The genes are inactivated. These findings mean that the chemical manipulation of these gene-activating enzymes may allow stem cells to specifically differentiate into bone cells, while inhibiting their differentiation into fat cells. The research team used aging mice as the research object and found that these two enzymes KDM4B and KDM6B can specifically activate genes that promote the differentiation of stem cells into bone cells, and at the same time block the differentiation of stem cells into fat cells. Dr. Wang said, "Interesting Yes, in aging mice and osteoporosis mice, we observed a higher percentage of silent histone methyl groups, while in younger and healthier mice, these methyl groups are usually It is removed by the enzymes KDM4B and KDM6B. Given that it is easy to modify these enzymes by chemical means, they are likely to be potential therapeutic targets for tissue regeneration and osteoporosis treatment. "Director of the UCLA School of Dentistry Dr. No-Hee Park said, "The findings made by Dr. Wang and his research team have a profound impact on craniofacial bone regeneration and osteoporosis treatment. As people age, osteoporosis and gum disease may be people The main health problem, the progress made in the treatment of aging-related is very valuable. " Double Wall Ice Bucket,Ice Bucket,Copper Champagne Bucket,Stainless Steel Champagne Bucket Xianke Metal Products Factory , https://www.stainlessbarware.com