After more than three years of clinical research, the group led by Professor Chen Haiquan of the Cancer Hospital of Fudan University has invented a molecular diagnostic technology that can quickly and accurately detect the lung cancer carrying the "ALK fusion gene", which can save patients a huge amount of testing costs and be advanced Lung cancer patients choose "specific" molecular targeted drugs for personalized treatment to win precious time. Related papers have been published in the recently published internationally renowned oncology journal "Clinical Cancer Research". "ALK fusion gene" is an oncogene, which exists in 3% -7% of non-small cell lung cancer. The molecular targeting drug Crizotinib targeting this oncogene can significantly improve the survival rate of lung cancer patients. However, how to quickly and accurately diagnose lung cancer carrying the "ALK fusion gene" has been a worldwide problem. At present, the international "ALK fusion gene" detection technology is complex, and it takes at least 2 days to complete, and the price per case is up to 1500 US dollars. Chen Haiquan accidentally discovered in a study that when the "ALK fusion gene" breaks, the expression of "kinase domain" in the human body will be significantly increased, while the expression of "non-kinase domain" is not or low. Based on this feature, Chen Haiquan's group creatively invented a new technology of "real-time quantitative ALK fusion gene detection", which can quickly and accurately diagnose ALK by detecting the difference in the expression level of ALK gene before and after the breakpoint of "ALK fusion gene" Fusion gene. It has been verified that the detection results of 950 non-small cell lung cancer specimens using this new technology have found 40 positive specimens carrying the "ALK fusion gene", with sensitivity and specificity of 100%. In addition, the technology also has the advantages of high throughput and low cost. It can complete the detection of 48 samples in 90 minutes, and the cost of each test does not exceed 30 yuan. It is reported that, in recognition of Chen Haiquan's outstanding contribution, the American College of Chest Physicians has decided to award it the "Alfred Sover Research Award" at the upcoming 2012 annual meeting. A gas grill is a type of outdoor grill that uses propane or natural gas
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