Cells use lipid to keep cilia up to find the direction of travel

Dr. Erhard Bieberich, Ph.D., biologist of the Georgia School of Medicine, University of Georgia Health Sciences, said that every cell has "tentacles" or cilia, which can sense the environment. To determine where the cell goes and what to do when it reaches it.

A cell needs an organelle to sense where it is so that it can go where it wants and needs to go.

Ceramide is actually a multi-tasker. The Bieberich research team reported in the Journal of Biological Chemistry in 2007 that during the earliest stages of development, it helped locate stem cells in order to determine which direction to go up and find the correct location where they are, and this location is more important for embryo generation. In 2004, the researchers discovered that lipid ceramide and protein PAR-4 cooperated to eliminate useless cells in the developing brain.

When cell division occurs, the cilia must be retracted, and activation of HDAC6 makes this retraction necessary under certain circumstances, such as drug development or when more skin cells or gastrointestinal cells are needed to replace normal turnover. Bieberich said that the interesting thing is that cancer cells are some of the fastest dividing cells, and "abuse" HDAC to achieve this; they also inhibit ceramide, because ceramide is known to induce cell suicide.

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