On October 10, the research team of Professor Zhang Xiaokun, an expert of the “Thousand Talents Program†of Xiamen University School of Pharmacy, published an important research paper in the internationally renowned oncology journal Oncogene. This research was conducted in cooperation with the research group of academician Yao Xinsheng, a famous natural product research expert in China. It made a new exploration of the mechanism and treatment of colon cancer, and discovered potential therapeutic targets and inhibitors for tumor cell growth. drug. β-catenin is a multifunctional protein, its main function is to mediate cell adhesion and participate in the regulation of gene expression, and its expression is closely regulated by APC and other related proteins; recent studies have shown that due to APC and its related genes The mutation that leads to abnormal accumulation of β-catenin is closely related to the occurrence of colon cancer. Therefore, looking for a new APC-independent β-catenin expression regulation pathway is extremely important for the treatment of colon cancer. The study found that the orphan nuclear receptor Nur77 can negatively regulate the expression of β-catenin through its non-genotypic function, thereby inhibiting the growth of tumor cells. At the same time, the study also found two cardiac glycoside compounds that can negatively regulate the expression of β-catenin by inducing the expression of Nur77: H-9 and ATE-i2-b4. The study proves that Nur77 can be used as a potential target for colon cancer treatment at the molecular, cellular and animal levels, and H-9 and ATE-i2-b4 may become potential drugs for the treatment of colon cancer. The first author of the paper is Sun Zhe, a doctoral student at the School of Pharmacy, Xiamen University; the corresponding authors are Professor Zhang Xiaokun and Academician Yao Xinsheng. In recent years, Professor Zhang Xiaokun and his research group have achieved many major achievements in the field of cancer research. They have published many papers in the international high-level journals with Xiamen University as the first or corresponding author unit. The magazine includes Cancer Cell (JCR Area 1) , Impact factor 26.925), Cancer Res (JCR first area, impact factor 8.234), FASEB J (JCR second area, impact factor 6.515), Oncogene (JCR first area, impact factor 7.414), etc. These innovative discoveries have very important theoretical and practical significance for humans to overcome cancer. ABLE Halloween Decor Fire Logs, made of light ceramic raw materials or cement materials, light weight but strong not easy to break, hand-painted, natural colors and amazing details & realistic shapes, easy turn redness in the fire, can enhance the fireplace flame, all made of inorganic materials, odorless, fire-resistant temperature >900℃, product can be used for a long time, with reasonable price. Halloween Decor Fire Log,Ceramic Halloween Decor Fire Log,Gas Fireplace Halloween Decor Logs,Fire Pit Halloween Decor Log Yixing Able Ceramic Fibre Products Co., Ltd , https://www.ablegaslogs.com
ABLE also have advanced molding technology for ceramic log called cast log, it is lighter, stronger, fuller details, and glowing area is larger in the fire.ABLE can supply many kind of log accessories for fireplace, such as pebbles, coals, charcoals, pine cones, maple leaves, aglow ember, top-grade rock wool, stained vermiculite, small coal chips, barks, balls and hollow ball, ceramic pitted pebble and rough Lava rock that won't burst in outdoor fire pit, Pumpkin lamp, Skull and bone for Halloween Decor fire, fireplace log grate etc.
ABLE factory is located in Yixing City, Jiangsu. It is a well-known production base for fire resistant insulation materials and environmental protection products. Yixing is also a city has developed commerce and convenient transportation. Our company sincerely hopes to cooperate with professional customers, and welcome to visit our factory!